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Vaginal dryness, loss of libido, and pain during sex are some of the most common sexual side effects of hormonal therapy to treat hormone-receptor-positive breast cancer. Still, a small study suggests that postmenopausal women with partners may have better quality of life than women without partners when experiencing a number of sexual side effects from breast cancer hormonal therapy. The research was published online on April 15, , by the journal Menopause. There are several types of hormonal therapy medicines. Tamoxifen, a selective estrogen receptor modulator SERM , is one of the most well-known.